ALLO-605 TurboCAR™: Turbocharging CAR T Cells

Cytokine stimulation can increase the potency and durability of engineered T cells

TurboCAR™ is designed to recapitulate cytokine signaling selectively in CAR T cells and may have potential benefits, subject to investigation

  • Minimizes systemic toxicity
  • Does not stimulate host immune cells which could reject CAR
  • Delivers survival benefit selectively to CAR T cells

Opportunities for development

  • Improving the efficacy of CAR T cells
  • Reducing CAR T cell dose requirement
  • Overcoming exhaustion to enable CAR T therapies to be used for solid tumors